Bioabsorbable Bone Plates Enabled With Local, Sustained Delivery of Bmp2 for Bone Regeneration

Effects of local delivery of BMP2, zoledronate and their combination on bone microarchitecture, biomechanics and bone turnover in osteoporotic rabbits

The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumulating evidence demonstrates the high bioavailability and therapeutic efficacy...

Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects

This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lact...

Injectable, Biodegradable Polyurethane Scaffolds With Local Lovastatin Delivery For Enhanced Bone Regeneration

Introduction: While autologous bone may be the ideal graft material for use in reconstructive orthopaedic surgery, its harvesting often causes donor site morbidity and has limited availability. Thus, synthetic or biological material substitutes have been increasingly studied for bone tissue repair. We have developed injectable biodegradable polyurethane (PUR) scaffolds with high porosity (>90%)...

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery.

This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as 'templated glasses' (TGs), which present chemical compositions similar to those of conventional bioactive sol-gel...

The effect of local delivery of Iron Chelators on Bone Regeneration and Osteoclast Mediated Bioceramic Bone Graft Resorption